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ABSTRACT Microfluidic devices (MDs) present a novel method for detecting circulating tumor cells (CTCs), enhancing the process through targeted techniques and visual inspection. However, current approaches often yield heterogeneous CTC populations, necessitating additional processing for comprehensive analysis and phenotype identification. These procedures are often expensive, time‐consuming, and need to be performed by skilled technicians. In this study, we investigate the potential of a cost‐effective and efficient hyperuniform micropost MD approach for CTC classification. Our approach combines mathematical modeling of fluid–structure interactions in a simulated microfluidic channel with machine learning techniques. Specifically, we developed a cell‐based modeling framework to assess CTC dynamics in erythrocyte‐laden plasma flow, generating a large dataset of CTC trajectories that account for two distinct CTC phenotypes. Convolutional neural network (CNN) and recurrent neural network (RNN) were then employed to analyze the dataset and classify these phenotypes. The results demonstrate the potential effectiveness of the hyperuniform micropost MD design and analysis approach in distinguishing between different CTC phenotypes based on cell trajectory, offering a promising avenue for early cancer detection. 

The unsigned p-Willmore functional introduced in the work of Mondino [2011] generalizes important geometric functionals, which measure the area and Willmore energy of immersed surfaces. Presently, techniques from the work of Dziuk [2008] are adapted to compute the first variation of this functional as a weak-form system of equations, which are subsequently used to develop a model for the p-Willmore flow of closed surfaces in R 3 . This model is amenable to constraints on surface area and enclosed volume and is shown to decrease the p-Willmore energy monotonically. In addition, a penalty-based regularization procedure is formulated to prevent artificial mesh degeneration along the flow; inspired by a conformality condition derived in the work of Kamberov et al. [1996], this procedure encourages angle-preservation in a closed and oriented surface immersion as it evolves. Following this, a finite-element discretization of both procedures is discussed, an algorithm for running the flow is given, and an application to mesh editing is presented. 

Abstract We present a novel preconditioning technique for Krylov subspace algorithms to solve fluid‐structure interaction (FSI) linearized systems arising from finite element discretizations. An outer Krylov subspace solver preconditioned with a geometric multigrid (GMG) algorithm is used, where for the multigrid level subsolvers, a field‐split (FS) preconditioner is proposed. The block structure of the FS preconditioner is derived using the physical variables as splitting strategy. To solve the subsystems originated by the FS preconditioning, an additive Schwarz (AS) block strategy is employed. The proposed FS preconditioner is tested on biomedical FSI applications. Both 2D and 3D simulations are carried out considering aneurysm and venous valve geometries. The performance of the FS preconditioner is compared with that of a second preconditioner of pure domain decomposition type.